Non-profit partnerships for pharmaceutical R&D
Volker Lehmann
Keywords:  Biotechnology programmes/networks, Private industry, Public institute, Drugs, Vaccine, AIDS, Malaria.
back to the article V. Lehmann: New models for public-private partnerships in drug development

G. Walt & L. Lush: Getting drugs to where they are needed: Global public private partnerships for neglected diseases

B. Levings & P. Kahn: Phase I DNA vaccine trial begins in Nairobi



Name Donors Finance Private sector partners Current projects Ownership snd patent stipulation
Global TB Alliance GF; RF Total of US$ 40 million Projects and partners are not yet disclosed TB drugs Some ownership of compounds; patents decided upon case-by case.
HIV Vaccine Design and Development Teams (HVDDT) * NIAID/NIH (USA) Total of US$ 70 million for 5 years Advanced BioScience Laboratories (USA); Chiron Corporation (USA); Wyeht Lederle Vaccines and Nutriton (USA) HIV vaccine; 4 vaccine projects; first clinical tests expected in 2002 US laws on publicly funded research (Baye-Dole-Act): The inventor gets the patent, but federal agencies can exert compulsory licencing.
International AIDS Vaccine Initiative GF; RF; other  philantropich institutions; WB; Internaltional development agencies from the UK, Canada, Ireland, the Netherlands Total of US$ 230 million until 2007 AlphaVax (USA); Targeted Genetics (USA); Therion Biologics (USA) 6 HIV vaccine candidates under development; one phase I trial in Kenya Patents go to private partners; IAVI stipulates prices and use of technologies.
Medicine for Malaria Venture (MMV) GF; RF; internationatl devlopment agencies from Switzerland, UK, the Netherlands; WB; WHO; Exxon Mobil (USA) Project funding: US$10 million in 2001; targeted for US$ 15 million in 2002 GlaxoSmithKline (UK); F. Hoffman-La Roche (Switzerland) 3 exporatory and 3 drug discovery projects funded for a total of US$ 4.2 million; 8 discovery and development projects to be added. Private partners receive patents in non-endemic countries and for applications other than malaria. MMV receives patents in disease-endemic countries and for treatment of malaria.
Malaria Vaccine Initatiave (MVI) GF Total of US$ 50 million for 5 years GlaxoSmithKline (UK); Apovia (Germany/USA) Phase I trials in Gambia for one candidate Patent belongs to private partners; if they abandon commercialization, MVI retains back-up development and manufacturing rights.

* Not a Virtual Pharmaceutical Company, but a US government programme to fund vaccine R&D in collaboration with private companies.

Table compiled by the author.

GF Bill & Melinda Gates Foundation http://www.gatesfoundation.org
NIAID/NIH National Institutes of Allergy and Infectious Diseases/
National Institutes of Health
RF The Rockefeller Foundation http://www.rockfound.org
WB World Bank http://www.worldbank.org
WHO World Health Organization http://www.who.int

Global TB Alliance The Global Alliance for TB Drug Development http://www.tballiance.org
HVDDT HIV Vaccine Design and Development Teams
IAVI International AIDS Vaccine Initiative http://www.iavi.org
MMV Medicine for Malaria Venture http://www.malariamedicines.org
MVI Malaria Vaccine Initiative www.malariavaccine.org

TB tuberculosis

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